A recent study by Kessler Foundation researchers provided new findings about the nature of social cognitive deficits in the population with progressive multiple sclerosis. 

The researchers conducted tests of social cognition in two groups: 15 individuals with progressive MS and 15 healthy controls. They used Virtual Assessment of Mentalising Ability to measure Theory of Mind in both groups. This was the first application of VAMA for research in the subtype of progressive MS. Results showed poorer performance on VAMA in the MS group and identified a specific deficit in the cognitive ToM subtest, which measures how well individuals can reason about the thoughts and intentions of others. In contrast, they found no differences between the groups on the affective ToM subtest, which measures how well individuals can reason about the emotions of others.

Deficits in social cognition that impair quality of life are associated with all types of MS, but appear to be more pronounced in progressive MS. Developing effective interventions depends upon expanding our knowledge of social cognitive deficits in progressive MS. Much of the research, however, has been conducted in relapsing remitting MS.

The article was published by the Journal of the International Neuropsychological Society.