Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54 Page 55 Page 56 Page 57 Page 58 Page 59 Page 60 Page 61 Page 62 Page 63 Page 64 Page 65 Page 6663 MSFocus Summer 2016 massive doses of vitamin D without guidance as there may be a higher risk of kidney stones with prolonged excessive dosing. Researchers Pioneer New MRI Technique for Use in MS A research team in the UK has found a way to use clinical MRI to distinguish between MS lesions and other brain white spots which are found in MS. The new study is significant because currently among patients referred to MS treatment centers with suspected MS, fewer than 50 percent are found to have it. This shows that diagnosing MS in a significant minority of cases can be challenging. Researchers at the University of Nottingham and Nottingham University Hospitals NHS Trust used a clinical MRI scanner to carry out a special type of scan, called a T2-weighted imaging process, which is able to reveal lesions in the brain’s white matter that are centered on a vein — a known indicator of MS. Lead researcher, Dr. Nikos Evangelou, said:“We wanted to find out whether a single brain scan in an NHS hospital scanner could also be effective in distinguishing between patients known to have MS and patients known to have non-MS brain lesions. We are excited to reveal that our results show that clinical application of this technique could supplement existing diagnostic methods for MS.” Forty patients were recruited from the Neurology Outpatients’ Department of Nottingham University Hospitals NHS Trust. A test group of 10 patients with MS and 10 patients with non-MS white brain matter lesions were scanned. Scans were analyzed blinded to clinical data and simple diagnostic rules were devised. The same rules were applied to a validation group of 20 patients.Within the test group, all patients with MS had central veins in more than 45 percent of brain lesions, while the rest had central veins visible in less than 45 percent of lesions. Then, by applying the same diagnostic rules to the second group, all the remaining patients were correctly categorized into MS or non-MS, by the blinded observer, taking less than two minutes per scan. The study is published in the Multiple Sclerosis Journal. Dr. Thrower: In the U.S., we currently have 13 FDA-approved therapies for relapsing forms of MS. For the past 20 years, research has consistently shown that the initiation of these drugs early in the course of MS has the greatest effect. Early treatment necessitates the early diagnosis of MS. While an early diagnosis is important, an accurate diagnosis is equally important. Brain MRI aids in both the diagnosis and monitoring of MS. The overwhelming majorityofpeoplewithMShave“whitespots” or lesions on brain MRI. Unfortunately, many other conditions can be associated with brain MRI abnormalities, including migraine headaches and small strokes. This new MRI technique described may allow for the more accurate diagnosis of MS and the avoidance of mistaken diagnoses. Any research advance that allows for the more timely and accurate diagnosis of MS is a step in the right direction. Infertility Treatments May Significantly Increase MS Activity A new study finds that women with MS who undergo infertility treatment with assisted reproduction technology (ART) are at risk for increased disease activity.