b'Consumer Brief SummaryThe risk information provided here is not comprehensive.clinically isolated syndromeThis information does not take the place of talking withrelapsing-remitting diseaseyour doctor about your medical condition or treatment. active secondary progressive diseaseTo learn more about KESIMPTA (ofatumumab) injections, talk to your doctor or pharmacist. For more informationIt is not known if KESIMPTA is safe or effective in children.and to obtain the FDA-approved product labeling, callDo not use KESIMPTA if you:1-888-669-6682 or visit www.kesimpta.com. have active hepatitis B virus infection.What is the most important information I should knowBefore using KESIMPTA, tell your healthcare provider about KESIMPTA? about all of your medical conditions, including if you:KESIMPTA can cause serious side effects, including: have or think you have an infection, including HBV or Infections. Serious infections can happen during PML. See What is the most important information Itreatment with KESIMPTA. If you have an active infection,should know about KESIMPTA?your healthcare provider should delay your treatment with KESIMPTA until your infection is gone. KESIMPTA takenhave ever taken, currently take, or plan to takebefore or after other medicines that weaken the immunemedicines that affect your immune system. Thesesystem may increase your risk of getting infections.medicines could increase your risk of getting aninfection.Tell your healthcare provider right away if you have anyhave had a recent vaccination or are scheduled toinfections or get any symptoms including painful and frequent urination, nasal congestion, runny nose, sorereceive any vaccinations.othroat, fever, chills, cough, or body aches.You should receive any required live or live-Hepatitis B virus (HBV) reactivation. Before starting attenuated vaccines at least 4 weeks before youstart treatment with KESIMPTA. You should nottreatment with KESIMPTA, your healthcare provider will receive live or live-attenuated vaccines while youdo blood tests to check for HBV. If you have ever had are being treated with KESIMPTA and until yourHBV infection, the HBV may become active again during healthcare provider tells you that your immune systemor after treatment with KESIMPTA. Hepatitis B virus is no longer weakened.becoming active again (called reactivation) may causeo Whenever possible, you should receive any non-liveserious liver problems including liver failure or death. Youshould not receive KESIMPTA if you have active hepatitis vaccines at least 2 weeks before you start treatmentB liver disease. Your healthcare provider will monitor with KESIMPTA.you for HBV infection during and after you stop using o Talk to your healthcare provider about vaccinations KESIMPTA. Tell your healthcare provider right away if for your baby if you used KESIMPTA during youryou get worsening tiredness or yellowing of your skin or pregnancy.white part of your eyes during treatment with KESIMPTA.are pregnant, think that you might be pregnant, or planProgressive Multifocal Leukoencephalopathy (PML). to become pregnant. It is not known if KESIMPTA will PML may happen with KESIMPTA. PML is a rare, serious harm your unborn baby. Females who can becomebrain infection caused by a virus that may get worse pregnant should use birth control (contraception) duringover days or weeks. PML can result in death or severe treatment with KESIMPTA and for 6 months after yourdisability. Tell your healthcare provider right away if last treatment. Talk with your healthcare provider aboutyou have any new or worsening neurologic signs or what birth control method is right for you during this time.symptoms. These may include weakness on one side ofyour body, loss of coordination in arms and legs, vision are breastfeeding or plan to breastfeed. It is not known problems, changes in thinking and memory which may if KESIMPTA passes into your breast milk. Talk to yourlead to confusion and personality changes. healthcare provider about the best way to feed yourbaby if you take KESIMPTA.Weakened immune system. KESIMPTA taken before orTell your healthcare provider about all the medicines after other medicines that weaken the immune systemyou take, including prescription and over-the-counter could increase your risk of getting infections. medicines, vitamins, and herbal supplements.What is KESIMPTA? Know the medicines you take. Keep a list of them to show KESIMPTA is a prescription medicine used to treat adultsyour healthcare provider and pharmacist when you get a with relapsing forms of multiple sclerosis (MS) including: new medicine.12060005_KSM_DTC_JLS_MS_Focus_M3FR.indd 2 12/13/23 11:26 AM'