Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54 Page 55 Page 56 Page 57 Page 58 Page 59 Page 60 Page 61 Page 62 Page 63 Page 64© 2016 Biogen. All rights reserved. 09/16 PLG-US-0616 225 Binney Street, Cambridge, MA 02142 • 1.800.456.2255 • PLEGRIDY.com Please see back cover to learn why PLEGRIDY® (peginterferon beta-1a) could be right for you. Important Safety Information (cont’d) • Take prescription and over-the-counter medicines, vitamins, and herbal supplements • Are pregnant or plan to become pregnant. It is not known if PLEGRIDY will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with PLEGRIDY • Are breastfeeding or plan to breastfeed. It is not known if PLEGRIDY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use PLEGRIDY PLEGRIDY can cause additional serious side effects including: • Serious allergic reactions. Serious allergic reactions can happen quickly. Symptoms may include itching, swelling of the face, eyes, lips, tongue, or throat, trouble breathing, feeling faint, anxiousness, skin rash, hives, or skin bumps • Injection site reactions. PLEGRIDY may commonly cause redness, pain or swelling at the place where the injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected and it does not heal within a few days. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider • Heart problems, including congestive heart failure. While PLEGRIDY is not known to have any direct effects on the heart, some people who did not have a history of heart problems developed heart muscle problems or congestive heart failure after taking interferon beta. If you already have heart failure, PLEGRIDY may cause your heart failure to get worse. Call your healthcare provider right away if you have worsening symptoms of heart failure such as shortness of breath or swelling of your lower legs or feet while using PLEGRIDY • Some people using PLEGRIDY may have other heart problems, including low blood pressure, fast or abnormal heart beat, chest pain, heart attack, or a heart muscle problem (cardiomyopathy) • Autoimmune diseases. Problems with easy bleeding or bruising (idiopathic thrombocytopenia), thyroid gland problems (hyperthyroidism and hypothyroidism), and autoimmune hepatitis have happened in some people who use interferon beta • Blood problems and changes in your blood tests. PLEGRIDY can decrease your white blood cells or platelets, which can cause an increased risk of infection, bleeding or anemia, and can cause changes in your liver function tests. Your healthcare provider should do blood tests while you use PLEGRIDY to check for side effects • Seizures. Some people have had seizures while taking PLEGRIDY, including people who have never had seizures before The most common side effects of PLEGRIDY include: • Flu-like symptoms. Many people who take PLEGRIDY have flu- like symptoms early in the course of therapy. These symptoms are not really the flu. You cannot pass it on to anyone else. Symptoms may include headache, muscle and joint aches, fever, chills or tiredness • You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers and drinking plenty of water. For many people, these symptoms lessen or go away over time Important Dosing Information • See the Instructions for Use for detailed instructions to prepare for and to inject your dose of PLEGRIDY • A healthcare provider should show you how to inject your PLEGRIDY before you use it for the first time • When you first use PLEGRIDY, your healthcare provider may tell you to slowly increase your dose so that you can adjust to the effects of PLEGRIDY before using the full dose. You should use a PLEGRIDY Starter Pack to slowly adjust your dose when you begin treatment • PLEGRIDY is given by an injection under the skin (subcutaneous injection) of your stomach, back of upper arm, or thigh 1 time every 14 days • Change the site you choose with each injection to help decrease the chance that you will have an injection site reaction • Talk to your doctor about premedication for management of potential flu-like symptoms Call your doctor for medical advice about side effects. You may report side effects to FDA at 1.800.FDA.1088. Please see adjacent page for Medication Guide and the back cover for additional Important Safety Information. This information is not intended to replace discussions with your doctor. For full Prescribing Information, please visit www.PLEGRIDY.com.