Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54 Page 55 Page 56 Page 57 Page 58 Page 59 Page 60 Page 61 Page 62 Page 63 Page 64 Page 65 Page 66 Page 67 Page 68What is TECFIDERA? Tecfidera® (dimethyl fumarate)is a prescription medicine used to treat people with relapsing forms of multiple sclerosis. Important Safety Information Do not use TECFIDERA if you have had an allergic reaction (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing) to TECFIDERA or any of its ingredients. Before taking and while you take TECFIDERA, tell your doctor about any low white blood cell counts or infections or any other medical conditions. What are the possible side effects of TECFIDERA? TECFIDERA may cause serious side effects including allergic reactions, PML, which is a rare brain infection that usually leads to death or severe disability, and decreases in your white blood cell count. Your doctor may check your white blood cell count before you take TECFIDERA and from time to time during treatment. The most common side effects of TECFIDERA include flushing and stomach problems. These can happen especially at the start of treatment and may decrease over time. Taking TECFIDERA with food may help reduce flushing. Call your doctor if these symptoms bother you or do not go away. Ask your doctor if taking aspirin before taking TECFIDERA may reduce flushing. Important Safety Information (continued) These are not all the possible side effects of TECFIDERA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information go to dailymed.nlm.nih.gov. Tell your doctor if you are pregnant or plan to become pregnant, or breastfeeding or plan to breastfeed. It is not known if TECFIDERA will harm your unborn baby or if it passes into your breast milk. Also tell your doctor if you are taking prescription or over-the- counter medicines, vitamins, or herbal supplements. For additional important safety information, please see Patient Information on the following page. This is not intended to replace discussions with your doctor. *Based on number of prescriptions from IMS NPA™ Weekly Data (September 27, 2013 – December 31, 2015). † Biogen data on file. © 2016 Biogen. All rights reserved. 3/16 TEC-US-1128 • 225 Binney Street, Cambridge, MA 02142 • 1-800-456-2255 • Tecfidera.com Consider TECFIDERA—a pill that has the strength to cut relapses in half. TECFIDERA is a twice-daily pill for relapsing multiple sclerosis (MS) that has been shown to cut relapses in half. During a 2-year study, TECFIDERA reduced risk of relapse by 49% compared with placebo. TECFIDERA is also proven to slow the development of brain lesions and delay the progression of physical disability. Over 190,000 people around the world have taken TECFIDERA.† Ask your doctor if you should too. Visit TecPerspective.com or call 1-844-TalkTec (1-844-825-5832) TECFIDERA is the PRESCRIBED PILL for relapsing MS in the US since September 2013.* 1 #