Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54 Page 55 Page 56 Page 57 Page 58 Page 59 Page 60 Page 61 Page 62 Page 63 Page 64 Page 65 Page 66 Page 67 Page 68Take control of your treatment with BETACONNECT. Call 1-800-788-1467 or visit BETACONNECT.com *Use the built-in reminder only as a backup. You still must take BETASERON on schedule and follow the instructions from your healthcare provider, even if you use the built-in reminder. † Before you change your injection depth or speed settings, talk with your healthcare provider or BETA Nurse. IMPORTANT SAFETY INFORMATION (CONTINUED) Seizures. Some people have had seizures while taking BETASERON, including people who have never had seizures before. It is not known if the seizures were related to MS, to BETASERON, or to a combination of both. If you have a seizure after taking BETASERON call your healthcare provider right away. Blood Problems. You may have a drop in the levels of infection- fighting white blood cells, red blood cells, or cells that help you form blood clots. If drops in levels are severe, they can lessen your ability to fight infections, make you feel tired or sluggish or cause you to bruise or bleed easily. Risk to Pregnancy: BETASERON can harm your unborn baby. BETASERON may cause you to lose your baby (miscarry). If you become pregnant while taking BETASERON call your healthcare provider right away. You and your healthcare provider should decide if you should continue to take BETASERON. Most Common Side Effects: The most common side effects of BETASERON include low white blood cell count, increaswes in your liver enzymes, headache, increase in your muscle tension, pain, rash, problems sleeping, stomach pain, weakness. These are not all the possible side effects of BETASERON. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Tell your healthcare provider about all the medicines you take and your medical conditions. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. Please see the brief summary of Medication Guide on the following page. Bayer, the Bayer cross, and BETASERON are registered trademarks of Bayer. BETACONNECT is a trademark of Bayer. ©2016 Bayer, Whippany, NJ 07981 All rights reserved. PP-621-US-0054 September 2016 References: 1. BETASERON (prescribing information). Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; Rev. 4/16. 2. Lublin F. History of modern multiple sclerosis therapy. J Neurol. 2005;252(suppl 3):iii3-iii9. 3. Food and Drug Administration press release, 07/23/1993. http://www.scienceblog.com/community/older/archives/M/1/fda0962.htm. Accessed August 23, 2016. 4. Ziemsson T, Sylvester L, Rametta M, et al. Patient satisfaction with the BETACONNECT autoinjector for interferon beta-1b. Poster presented at: The 2015 Annual Meeting of the Consortium of Multiple Sclerosis Centers (CMSC); May 2015; Indianapolis, IN. would most likely/probably recommend BETACONNECT to a friend4 felt BETACONNECT’s function and features are good, very good, or satisfactory4 Here’s what BETACONNECT users are saying: In a survey of 1365 patients that evaluated their satisfaction with BETACONNECT…4 BETASERON brings you BETACONNECT The FIRST AND ONLY electronic autoinjector in relapsing-remitting multiple sclerosis (RRMS) treatment that offers: • Automatic needle insertion and retraction (once injection is complete) • A built-in injection reminder so you know when it’s time for your next injection* • Adjustable injection speed and depth settings based on your needs† Exclusively for