b'Brief Summary of Information About ZEPOSIA (zeh-poe-see-ah) (ozanimod) capsules Rx OnlyThis information does not take the place of talking with your take certain medicines called monoamine oxidase (MAO) healthcare provider about your medical condition or treatment.inhibitors (e.g., selegiline, phenelzine, linezolid).If you have any questions about ZEPOSIA (ozanimod), askTalk to your healthcare provider before taking ZEPOSIA if you your healthcare provider. Only your healthcare provider canhave any of these conditions or do not know if you have any determine if ZEPOSIA is right for you.of these conditions. What is the most important information I should know aboutBefore taking ZEPOSIA, tell your healthcare provider about ZEPOSIA?all of your medical conditions, including if you: ZEPOSIA may cause serious side effects, including: have a fever or infection, or you are unable to fight infections 1.Infections. ZEPOSIA can increase your risk of seriousdue to a disease or take or have taken medicines that lowerinfections that can be life-threatening and cause death.your immune system. ZEPOSIA lowers the number of white blood cells received a vaccine in the past 30 days or are scheduled to(lymphocytes) in your blood. This will usually go back receive a vaccine. ZEPOSIA may cause vaccines to be less to normal within 3 months of stopping treatment. Youreffective. healthcare provider may do a blood test of your white Before you start treatment with ZEPOSIA, your healthcare blood cells before you start taking ZEPOSIA.provider may give you a chicken pox (Varicella Zoster Virus)Call your healthcare provider right away if you have anyvaccine if you have not had one before.of the following symptoms of an infection during have had chickenpox or have received the vaccine for treatment with ZEPOSIA and for 3 months after your lastchickenpox. Your healthcare provider may do a blood test for dose of ZEPOSIA:the chickenpox virus. You may need to get the full course offeverrashthe vaccine for chickenpox and then wait 1 month before youfeeling very tired headache with fever, neck stiffness,start taking ZEPOSIA. flu-like symptoms sensitivity to light, nausea or have a slow heart rate.coughconfusion (these may be symptoms have an irregular or abnormal heartbeat (arrhythmia).painful and frequentof meningitis, an infection of have a history of a stroke. urination (signs of athe lining around your brain have heart problems, including a heart attack or chest pain.urinary tract infection) and spine) have high blood pressure. Your healthcare provider may delay starting or may stop have liver problems.your ZEPOSIA treatment if you have an infection. have breathing problems, including during your sleep. 2.Slow heart rate (also known as bradyarrhythmia) when have eye problems, especially an inflammation of the eye you start taking ZEPOSIA. ZEPOSIA may cause yourcalled uveitis. heart rate to temporarily slow down, especially duringhave diabetes. the first 8 days that you take ZEPOSIA. You will have a are pregnant or plan to become pregnant. ZEPOSIA may harm test to check the electrical activity of your heart called anyour unborn baby. Talk with your healthcare provider if you electrocardiogram (ECG) before you take your first doseare pregnant or plan to become pregnant. If you are a female of ZEPOSIA. Call your healthcare provider if you experiencewho can become pregnant, you should use effective birth the following symptoms of slow heart rate:control during your treatment with ZEPOSIA and for 3 monthsdizziness shortness of breathafter you stop taking ZEPOSIA. Talk with your healthcarelightheadednessconfusionprovider about what birth control method is right for youfeeling like your heart chest painduring this time. Tell your healthcare provider right away if is beating slowly ortirednessyou become pregnant while taking ZEPOSIA or if you become skipping beatspregnant within 3 months after you stop taking ZEPOSIA.Follow directions from your healthcare provider when are breastfeeding or plan to breastfeed. It is not known if starting ZEPOSIA and when you miss a dose. See HowZEPOSIA passes into your breast milk. Talk to your healthcare should I take ZEPOSIA?.provider about the best way to feed your baby if you take See What are the possible side effects of ZEPOSIA? forZEPOSIA. more information about side effects.Tell your healthcare provider about all the medicines you What is ZEPOSIA?take or have recently taken, including prescription and ZEPOSIA is a prescription medicine used to treat relapsingover-the-counter medicines, vitamins, and herbal supplements. forms of multiple sclerosis (MS), to include clinicallyUsing ZEPOSIA with other medicines can cause serious side isolated syndrome, relapsing-remitting disease, and activeeffects. Especially tell your healthcare provider if you take oresecondary progressive disease, in adults.have taken: It is not known if ZEPOSIA is safe and effective in children. medicines that affect your immune system, such asDo not take ZEPOSIA if you:alemtuzumabhave had a heart attack, chest pain (unstable angina), stroke medicines to control your heart rhythm (antiarrhythmics), oror mini-stroke (transient ischemic attack or TIA), or certainheart beat types of heart failure in the last 6 months. strong CYP2C8 inhibitors such as gemfibrozil or clopidogrelhave or have had a history of certain types of an irregular or medicines that inhibit breast cancer resistance protein abnormal heartbeat (arrhythmia) that is not corrected by atransporters, such as cyclosporine and eltrombopagpacemaker. CYP2C8 inducers such as rifampinhave untreated, severe breathing problems during your sleep opioids (pain medicine) (sleep apnea). medicines to treat depressionmedicines to treat Parkinsons disease1'