b'Brief Summary of Information About ZEPOSIA (zeh-poe-see-ah) (ozanimod) capsules Rx Only You should not receive live vaccines during treatment with a problem with your vision called macular edema. Your ZEPOSIA, for at least 1 month before taking ZEPOSIA and forrisk for macular edema is higher if you have diabetes or3 months after you stop taking ZEPOSIA. Vaccines may nothave had an inflammation of your eye called uveitis. Your work as well when given during treatment with ZEPOSIA.healthcare provider should test your vision before you start Talk with your healthcare provider if you are not sure if youtaking ZEPOSIA if you are at higher risk for macular edema take any of these medicines.or at any time you notice vision changes during treatment Know the medicines you take. Keep a list of them to show yourwith ZEPOSIA. Call your healthcare provider right away if healthcare provider and pharmacist when you get a new medicine.you have any of the following symptoms: How should I take ZEPOSIA? blurriness or shadows in a blind spot in the center You will receive a 7-day starter pack. You must start ZEPOSIAthe center of your vision of your visionby slowly increasing doses over the first week. Follow the sensitivity to lightunusually colored vision dose schedule in the table below. This may reduce the risk swelling and narrowing of blood vessels in your brain. A of slowing of the heart rate.condition called PRES (Posterior Reversible Encephalopathy Days 1-4 Take 0.23 mg (capsule in light greySyndrome) is a rare condition that has happened with color) 1 time a day ZEPOSIA and with drugs in the same class. Symptoms of PRES usually get better when you stop taking ZEPOSIA.Days 5-7 Take 0.46 mg (capsule in half-light greyIf left untreated, it may lead to a stroke. Your healthcare and half-orange color) 1 time a day provider will do a test if you have any symptoms of PRES. Days 8 and thereafter Take 0.92 mg (capsule in orangeCall your healthcare provider right away if you have any ofcolor) 1 time a day the following symptoms:Take ZEPOSIA exactly as your healthcare provider tells you sudden severe headache sudden loss of vision or s to take it.sudden confusion other changes in your vision cTake ZEPOSIA 1 time each day. seizure oSwallow ZEPOSIA capsules whole. severe worsening of multiple sclerosis (MS) after stopping tTake ZEPOSIA with or without food.ZEPOSIA. When ZEPOSIA is stopped, symptoms of MS mayuaAvoid certain foods that are high (over 150 mg) in tyraminereturn and become worse compared to before or during such as aged, fermented, cured, smoked and pickled foods.treatment. Always talk to your healthcare provider beforeEating these foods while taking ZEPOSIA may increase youryou stop taking ZEPOSIA for any reason. Tell your healthcare blood pressure.provider if you have worsening symptoms of MS afterDo not stop taking ZEPOSIA without talking with yourstopping ZEPOSIA.healthcare provider first. allergic reactions. Call your healthcare provider if you haveDo not skip a dose.symptoms of an allergic reaction, including a rash, itchyStart taking ZEPOSIA with a 7-day starter pack.hives, or swelling of the lips, tongue or face.If you miss 1 or more days of your ZEPOSIA dose during theThe most common side effects of ZEPOSIA can include: first 14 days of treatment, talk to your healthcare provider. upper respiratory tract infections You will need to begin with another ZEPOSIA 7-day starter elevated liver enzymespack. low blood pressure when you stand up (orthostatic hypotension) If you miss a dose of ZEPOSIA after the first 14 days of painful and frequent urination (signs of urinary tract infection) treatment, take the next scheduled dose the following day. back pain What are the possible side effects of ZEPOSIA? high blood pressure ZEPOSIA can cause serious side effects, including: These are not all of the possible side effects of ZEPOSIA.See What is the most important information I shouldFor more information, ask your healthcare provider or know about ZEPOSIA?pharmacist. Call your healthcare provider for medicalliver problems. ZEPOSIA may cause liver problems. Youradvice about side effects. You may report side effects to healthcare provider will do blood tests to check your liverFDA at 1-800-FDA-1088. before you start taking ZEPOSIA. Call your healthcareGeneral information about the safe and effective use ofprovider right away if have any of the following symptoms:ZEPOSIA.unexplained nausea loss of appetiteMedicines are sometimes prescribed for purposes other thanvomiting yellowing of the whites of yourthose listed in a Medication Guide. Do not take ZEPOSIA for stomach areaeyes or skinconditions for which it was not prescribed. Do not give ZEPOSIA (abdominal) pain dark colored urineto other people, even if they have the same symptoms tirednessyou have. It may harm them. You can ask your healthcareincreased blood pressure. Your healthcare provider shouldprovider or pharmacist for information about ZEPOSIA that is check your blood pressure during treatment with ZEPOSIA.written for health professionals. For more information, callA sudden, severe increase in blood pressure (hypertensive1-833-ZEPOSIA (1-833-937-6742) or go to ZEPOSIA.com. crisis) can happen when you eat certain foods that containManufactured for: Celgene Corporation, Summit, NJ 07901 high levels of tyramine. See How should I take ZEPOSIA? Patent: www.celgene.com/therapies section for more information.breathing problems. Some people who take ZEPOSIA haveZEPOSIA is a trademark of Celgene, a Bristol-Myers Squibb shortness of breath. Call your healthcare provider right awayCompany if you have new or worsening breathing problems. 2020 Bristol-Myers Squibb Company1'