b'Medicine & ResearchSpasticity agents clinical review analyzing four separate clinical Tizanidine and baclofentrials concluded that approximately 40 percent are commonly used for theof patients with moderate-to-severe spasticity treatment of MS-associatedresistant to other spasticity treatment achieved spasticity. Both medicationsimprovement in spasticity-associated symptoms, cause sedation as a side effect.including improvements in sleep quality.Therefore, it is expected that these agents allowIt remains unclear if improvements in sleep patients to fall asleep easily and stay asleep.for patients taking a spasticity-treatment drug Polysomnographicmonitoring,anobjectiveis a direct effect of the drug itself or a secondary way to measure sleep quality, showed thateffect caused by improved spasticity control.patients taking either of these medicationsMonoclonal antibodiesexperienced increased total sleep time and reduced nighttime awakenings.Researchregardingthe Cannabis-derivedeffects of various monoclonal products such as Sativexantibodies on sleep is limited. (nabiximols),anoralNatalizumab, a monoclonal spray, have been shownantibody, is one of the few toimprovesleepfordrugs of its class with the MS patients. Patientsmost literature on its effect taking cannabinoid products have reportedon sleep. It has been shown to improve fatigue less sleep disruptions. However, some daytimeand daytime sleepiness in MS patients for up to sleepinesshasalsobeenreportedasanat least one year. The NAPS-MS trial found unwanted side effect. It is worth noting thatthat although natalizumab was associated cannabis-derived products help improve painwithpatientreportsofimprovementsin and spasticity, which often plague MS patientssleep, it failed to produce improvements in and can interfere with their sleep. A 2015sleep efficiency based on objective measures.Sleep recommendations for individuals with MS1. Stay consistent: Establish a bedtime routine and try to go to sleep at the same time every day, even on weekends. This can be especially helpful for people who work evenings or overnight. 2. Create a sleep-promoting environment: Keep the bedroom dim or dark, quiet, and at a comfortable temperature. Relaxation-inducing bedroom accessories such as blackout curtains, sound machines, or relaxation apps can help some people fall asleep faster. 3. Limit stimulants: Reduce caffeine and alcohol intake, especially in the afternoon and evening. 4. Physical activity: Engage in regular exercise but avoid vigorous activity close to bedtime. 5. Technology use: Minimize screen time before bed. This includes avoiding or limiting the use of mobile devices, computers, and television right before bedtime. It is thought that blue light emitted from such devices can interfere with your natural production of melatonin, a hormone that promotes sleep. msfocusmagazine.org 12'