b'Living with relapsing multiple sclerosis (MS)? TAKE A LOOKat a o t a once-daily py pill lfor rr relapsing Mg MSAsk your healthcare professional about ZEPOSIA at your next appointment.People had fewer relapses with ZEPOSIA fewer relapses 38 fewer relapses In a one-year study: In a separate two-year study: People who took ZEPOSIA had 48%People who took ZEPOSIA had fewer relapses than those who took a38% fewer relapses than those who leading injectable medicine (Avonex).took a leading injectable.*To learn more, visit ZEPOSIA.com/results or scan this QR code.*Avonex (interferon beta-1a).One-year study: People taking ZEPOSIA had an Annualized Relapse Rate (ARR) of 0.181 vs 0.350 with a leading injectable.A total of 895 people were studied (ZEPOSIA 447, a leading injectable 448). Two-year study: 0.172 ARR with ZEPOSIA vs 0.276 with a leading injectable. A total of 874 people were studied (ZEPOSIA 433, a leading injectable 441). INDICATIONZEPOSIA (ozanimod) is a prescription medicine used to treatZEPOSIA may cause serious side effects, including:relapsing forms of multiple sclerosis (MS), to include clinically Infections. ZEPOSIA can increase your risk of serious isolated syndrome, relapsing-remitting disease, and activeinfections that can be life-threatening and cause death. secondary progressive disease, in adults. ZEPOSIA lowers the number of white blood cells (lymphocytes) It is not known if ZEPOSIA is safe and effective in children. in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider IMPORTANT SAFETY INFORMATION may do a blood test of your white blood cells before you start Do not take ZEPOSIA if you: taking ZEPOSIA. have had a heart attack, chest pain (unstable angina), strokeCall your healthcare provider right away if you have any of or mini-stroke (transient ischemic attack or TIA), or certainthese symptoms of an infection during treatment with ZEPOSIA types of heart failure in the last 6 months and for 3 months after your last dose of ZEPOSIA: have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected byfeverrasha pacemakerfeeling very tiredheadache with fever, neckhave untreated, severe breathing problems during your sleepu-like symptoms stiffness, sensitivity to light, (sleep apnea) cough nausea, or confusion (symptomstake certain medicines called monoamine oxidasepainful and frequentof meningitis, an infection of the(MAO) inhibitors urination (signs of alining around your brain Talk to your healthcare provider before taking ZEPOSIA if youurinary tract infection) and spine)have any of these conditions or do not know if you have any ofYour healthcare provider may delay starting or may stop your these conditions. ZEPOSIA treatment if you have an infection. 1'