b'IMPORTANT INFORMATION ABOUT MAVENCLAD (cladribine) tablets, for oral use ooRead this information carefully before using It is not known if MAVENCLAD is safe and e\x1eective in rMAVENCLAD and each time you get a rell, as there children under 18 years of age. may be new information. This information does not take Do not take MAVENCLAD if you: y the place of talking with your healthcare provider (HCP). t What is the most important information I should know ohave cancer (malignancy). about MAVENCLAD? oare pregnant, plan to become pregnant, or are hMAVENCLAD can cause serious side e\x1eects, including: a woman of childbearing age or a man able to father aa child and you are not using birth control. See toRisk of cancer (malignancies). Treatment with sc What is the most important information I shouldMAVENCLAD may increase your risk of developing know about MAVENCLAD? tC cancer. Talk to your healthcare provider about your t arisk of developing cancer if you receive MAVENCLAD. oare human immunodeciency virus (HIV) positive. You should follow your healthcare provider ohave active infections, including tuberculosis (TB),instructions about screening for cancer. hepatitis B or C. oMAVENCLAD may cause birth defects if used duringoare allergic to cladribine.pregnancy. Females must not be pregnant when oare breastfeeding. See Before you take MAVENCLAD, they start treatment with MAVENCLAD or become pregnant during MAVENCLAD dosing and within tell your healthcare provider about all of your 6 months after the last dose of each yearly medical conditions, including if you: treatment course. Stop your treatment with Before you take MAVENCLAD, tell your healthcareMAVENCLAD and call your healthcare provider provider about all of your medical conditions, right away if you become pregnant during including if you:c treatment with MAVENCLAD. t othink you have an infection. For females who are able to become pregnant: e ohave heart failure. hYour healthcare provider should order a F pregnancy test for you before you begin your ohave liver or kidney problems. wS r rst and second yearly treatment course of ohave taken, take, or plan to take medicines that htMAVENCLAD to make sure that you are not s pregnant. Your healthcare provider will decide a\x1eect your immune system or your blood cells, or owhen to do the test. other treatments for MS. Certain medicines can w increase your risk of getting an infection. iUse e\x1eective birth control (contraception) on the ohave had a recent vaccination or are scheduled toc days on which you take MAVENCLAD and for atleast 6 months after the last dose of each yearly receive any vaccinations. You should not receive live i or live-attenuated vaccines within the 4 to 6 weeks o treatment course. preceding your treatment with MAVENCLAD. You s should not receive these types of vaccines duringd Talk to your healthcare provider if you use oral icontraceptives (the pill). your treatment with MAVENCLAD and until your You should use a second method of birth control healthcare provider tells you that your immune s on the days on which you take MAVENCLAD and system is no longer weakened.for at least 4 weeks after your last dose of each ohave or have had cancer.yearly treatment course. oare breastfeeding or plan to breastfeed. It is notFor males with female partners who are able toknown if MAVENCLAD passes into your breast milk. d become pregnant: Do not breastfeed on the days on which you take bhC Use e\x1eective birth control (contraception) during MAVENCLAD, and for 10 days after the last dose. SYthe days on which you take MAVENCLAD and See Do not take MAVENCLAD if you: C for at least 6 months after the last dose of each Tell your healthcare provider about all the medicines a yearly treatment course. you take, including prescription and over-the-countero What is MAVENCLAD? medicines, vitamins, and herbal supplements. DMAVENCLAD is a prescription medicine used to treat How should I take MAVENCLAD? orelapsing forms of multiple sclerosis (MS), to includeo relapsing remitting disease and active secondary Limit contact with your skin. Avoid touching yourprogressive disease, in adults. Because of its safety nose, eyes and other parts of the body. If you getprole, MAVENCLAD is generally used in people who MAVENCLAD on your skin or on any surface, wash ithave tried another MS medicine that they could not right away with water.tolerate or that has not worked well enough. o Take MAVENCLAD at least 3 hours apart from otherMAVENCLAD is not recommended for use in people medicines taken by mouth during the 4- to 5-daywith clinically isolated syndrome (CIS). MAVENCLAD treatment week.'