b'o If you miss a dose, take it as soon as you remember decreased strengthon the same day. If the whole day passes before youproblems with balanceremember, take your missed dose the next day. Mc Do not take 2 doses at the same time. Instead, changes in your visionmyou will extend the number of days in that changes in your thinking or memory t treatment week. confusion Your healthcare provider will continue to monitor yourahealth during the 2 yearly treatment courses, and for changes in your personalityaat least another 2 years during which you do not need oliver problems. MAVENCLAD may cause liver problems. a to take MAVENCLAD. It is not known if MAVENCLAD is Your healthcare provider should do blood tests to safe and eective in people who restart MAVENCLAD check your liver before you start taking MAVENCLAD.Mk treatment more than 2 years after completing 2 yearly Call your healthcare provider right away if you havectreatment courses.any of the following symptoms of liver problems:rWhat are the possible side e\x0bects of MAVENCLAD? nauseaY MAVENCLAD can cause serious side e\x0bects, including: vomitingi hoSee What is the most important informations tomach pain I should know about MAVENCLAD? t iredness ol ow blood cell counts. Low blood cell counts have loss of appetite thappened and can increase your risk of infections m during your treatment with MAVENCLAD. Your your skin or the whites of your eyes turn yellowhealthcare provider will do blood tests before dark urineyou start treatment with MAVENCLAD, during o allergic reactions (hypersensitivities). MAVENCLAD your treatment with MAVENCLAD, and afterward, can cause serious allergic reactions. Stop youras needed. treatment with MAVENCLAD and go to the closesto serious infections such as:emergency room for medical help right away if youTB, hepatitis B or C, and shingles (herpes zoster). have any signs or symptoms of allergic reactions. YFatal cases of TB and hepatitis have happenedSymptoms of an allergic reaction may include: skinpwith cladribine during clinical studies. Tell your rash, swelling or itching of the face, lips, tongue or healthcare provider right away if you get any throat, or trouble breathing.Masymptoms of the following infection related problemspoor if any of the symptoms get worse, including: oheart failure. MAVENCLAD may cause heart failure,w if everwhich means your heart may not pump as well asUit should. Call your healthcare provider or go to thedaching painful muscles closest emergency room for medical help right awaylrheadache if you have any signs or symptoms such as shortnessoof breath, a fast or irregular heart beat, or unusualt p f eeling of being generally unwellswelling in your body. Your healthcare provider may s l oss of appetite delay or completely stop treatment with MAVENCLADc y burning, tingling, numbness or itchiness of the if you have severe side eects.hskin in the aected areaThe most common side e\x0bects of MAVENCLAD include:o s s kin blotches, blistered rash and severe pain o upper respiratory infection fprogressive multifocal leukoencephalopathy (PML).o headache yPML is a rare brain infection that usually leads to o low white blood cell countskdeath or severe disability. Although PML has notb Dbeen seen in MS patients taking MAVENCLAD, it may These are not all the possible side eects of MAVENCLAD.UMhappen in people with weakened immune systems. Call your doctor for medical advice about side eects.tSymptoms of PML get worse over days to weeks. You may report side eects to FDA at 1-800-FDA-1088.S Call your healthcare provider right away if you have Distributed by: EMD Serono, Inc., Rockland, MA 02370f any new or worsening neurologic signs or symptoms y y of PML, that have lasted several days, including: MAVENCLAD is a registered trademark of Merck KGaA,Darmstadt, Germany.weakness on 1 side of your body For more information, call toll-free 1-877-447-3243 loss of coordination in your arms and legs or go to www.mavenclad.comr rpn pM hrtm w M 2019 EMD Serono, Inc.All rights reserved.US/CLA/0619/0371Printed in USA07/19'